ATG8ylation of proteins: A way to cope with cell stress?
Julian M. Carosi, Thanh Ngoc Nguyen, Michael Lazarou, Sharad Kumar, Timothy J. Sargeant
Abstract
The ATG8 family of proteins regulates autophagy in a variety of ways. Recently, ATG8s were demonstrated to conjugate directly to cellular proteins in a process termed "ATG8ylation," which is amplified by mitochondrial damage and antagonized by ATG4 proteases. ATG8s may have an emerging role as small protein modifiers.
Topics & Concepts
BiologyProteasesAutophagyCell biologyATG8CellMitochondrionGeneticsBiochemistryApoptosisEnzymeAutophagy in Disease and TherapyEndoplasmic Reticulum Stress and DiseaseCRISPR and Genetic Engineering