A nucleotidyltransferase toxin inhibits growth of <i>Mycobacterium tuberculosis</i> through inactivation of tRNA acceptor stems
Yiming Cai, B. F. Usher, Claude Gutierrez, Anastasia Tolcan, Moïse Mansour, Peter C. Fineran, Ciarán Condon, Olivier Neyrolles, Pierre Genevaux, Tim R. Blower
Abstract
tRNAs. Our study identifies a previously unknown mechanism that expands the range of enzymatic activities used by bacterial toxins, uncovering a new way to block protein synthesis and potentially treat tuberculosis and other infections.
Topics & Concepts
NucleotidyltransferaseTransfer RNAMycobacterium tuberculosisToxinMicrobiologyVirologyBiologyChemistryTuberculosisBiochemistryRNAMedicineGenePathologyRNA modifications and cancerTuberculosis Research and EpidemiologyBiochemical and Molecular Research