Obesity is positively Associated with Depression in Older Adults: Role of Systemic Inflammation.
Ye Xin Guo, An Qi Wang, Xin Gao, Jun Na, Zhe Wei, Yi Zeng, Jing rui Zhang, Yuan Jing Jiang, Fei Yan, Mukaram Yunus, Hui Wang, Zhao Yin
Abstract
Objective: We aimed to explore the association between obesity and depression and the role of systemic inflammation in older adults. Methods: = 1,973) were interviewed at baseline in 2018 and 1,459 were followed up in 2021. General and abdominal obesity were assessed, and serum C-reactive protein (CRP) levels were measured at baseline. Depression status was assessed at baseline and at follow-up. Logistic regression was used to analyze the relationship between obesity and the incidence of depression and worsening of depressive symptoms, as well as the relationship between obesity and CRP levels. The associations of CRP levels with the geriatric depression scale, as well as with its three dimensions, were investigated using multiple linear regressions. Results: < 0.05. Conclusion: General obesity, rather than abdominal obesity, was associated with worsening depressive symptoms and incident depression, which can be partly explained by the systemic inflammatory response, and the impact of obesity on depression should be taken more seriously in the older male population.