Construction of enantiopure imine bridged benzo[<i>c</i>]azepinones by a silver(<scp>i</scp>) and chiral N-heterocyclic carbene multicatalytic reaction sequence of <i>N</i>′-(2-alkynylbenzylidene)hydrazides and cyclopropanecarbaldehydes
Jin-Tao Ma, Ying Cheng
Abstract
A novel and efficient method for the synthesis of enantiopure bridged benzo[<italic>c</italic>]azepinone compounds has been developed by metal/N-heterocyclic carbene multicatalysis.
Topics & Concepts
Enantiopure drugChemistryCarbeneImineSequence (biology)StereochemistryMedicinal chemistryEnantioselective synthesisOrganic chemistryCatalysisBiochemistryN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCyclopropane Reaction MechanismsSynthetic Organic Chemistry Methods