Targeting intracellular pathways in idiopathic inflammatory myopathies: A narrative review
Gaetano La Rocca, Francesco Ferro, Chiara Baldini, Alessandro Libra, Domenico Sambataro, Michele Colaci, Lorenzo Malatino, Stefano Palmucci, Carlo Vancheri, Gianluca Sambataro
Abstract
In recent decades, several pieces of evidence have drawn greater attention to the topic of innate immunity, in particular, interferon (IFN) and Interleukin 6 in the pathogenesis of idiopathic inflammatory myopathies (IIM). Both of these molecules transduce their signal through a receptor coupled with Janus kinases (JAK)/signal transducer and activator of transcription proteins (STAT). In this review, we discuss the role of the JAK/STAT pathway in IIM, evaluate a possible therapeutic role for JAK inhibitors in this group of diseases, focusing on those with the strongest IFN signature (dermatomyositis and antisynthetase syndrome).