Light-Induced 1,3-Thiosulfonylation of β,γ-Unsaturated Ketones with Thiosulfonates
Jiuwen Xu, Bo-Xi Liu, Xinyu Liu, Weidong Rao, Shun‐Yi Wang
Abstract
Sulfur-containing compounds exhibit potent significance in drug molecules. Thiosulfonates as 1,3-thiosulfonylation reactants to olefins have yet to be investigated. Herein, we report photoinduced 1,3-difunctionalization of β,γ-unsaturated ketones with thiosulfonates, which undergo a radical 1,2-acyl shift. The protocol features mild conditions, high regioselectivity, and 100% atom economy.
Topics & Concepts
ChemistryRegioselectivitySulfurMoleculeMedicinal chemistryPhotochemistryCombinatorial chemistryOrganic chemistryCatalysisSulfur-Based Synthesis TechniquesRadical Photochemical ReactionsChemical Synthesis and Reactions