Targeting FoxO transcription factors with HDAC inhibitors for the treatment of osteoarthritis
Hiroki Ohzono, Yiwen Hu, Keita Nagira, Haruhisa Kanaya, Naoki Okubo, Merissa Olmer, Masafumi Gotoh, Ichiro Kurakazu, Yukio Akasaki, Manabu Kawata, Emily Chen, Alan C Chu, Kristen A Johnson, Martin Lotz
Topics & Concepts
PanobinostatMedicineFOXO1OsteoarthritisCancer researchHistone deacetylaseAutophagyCartilageTIMP1Transcription factorArthritisChondrocyteCell biologyPharmacologyImmunologyGene expressionHistoneApoptosisSignal transductionBiologyPathologyGeneAlternative medicineBiochemistryAnatomyProtein kinase BOsteoarthritis Treatment and MechanismsFOXO transcription factor regulationBone Metabolism and Diseases