Mesenchymal Stem Cell-Secreted Exosome Promotes Chemoresistance in Breast Cancer via Enhancing miR-21-5p-Mediated S100A6 Expression
Tao Luo, Qiaoyuan Liu, Aihua Tan, Lixia Duan, Yuxian Jia, Nong Li, Jing Tang, Wenxian Zhou, Weimin Xie, Yongkui Lu, Qiang Yu, Yan Liu
Abstract
, a chemoresistant gene, as a top-ranked gene induced by MSC-exo in BCs, which was further enhanced by Dt-MSC-exo. Furthermore, we found that Dox induced the expression of miR-21-5p in MSCs and MSC-exo, which was required for the expression of S100A6 in BCs. Importantly, silencing of miR-21-5p expression in MSCs and MSC-exo abolished the resistance of BCs to Dox, indicating an exosomal miR-21-5p-regulated S100A6 in chemoresistance. Our study thus uncovered a novel mechanistic insight into the role of MSC-secreted exosome in the development of chemoresistance in the tumor microenvironment.
Topics & Concepts
Mesenchymal stem cellExosomeMicrovesiclesmicroRNACancer researchBreast cancerCellBiologyMCF-7CancerCancer stem cellStem cellCell biologyHuman breastGeneGeneticsExtracellular vesicles in diseaseMicroRNA in disease regulationCircular RNAs in diseases