Sea cucumber chondroitin sulfate polysaccharides attenuate OVA-induced food allergy in BALB/c mice associated with gut microbiota metabolism and Treg cell differentiation
Cheng Li, Yang Tian, Jiahuan Pei, Yuyang Zhang, Daokuan Hao, Tian-Jiao Han, Xiaoqin Wang, Shuang Song, Linjuan Huang, Zhongfu Wang
Abstract
, and up-regulated the secretion of short chain fatty acids such as butyric acid in the feces, resulting in an increase in the mucin 2 (MUC2) secretion by goblet cells HT-29. Meanwhile, SCCS induced the differentiation of regulatory T cells in the mesenteric lymph nodes of mice. This study provides a deeper understanding of the functioning mechanism of SCCS in alleviating food allergy and may guide the development and production of anti-allergy active ingredients.
Topics & Concepts
Chondroitin sulfateOvalbuminAllergyLachnospiraceaeImmune systemImmunologyMesenteric lymph nodesBiologyChemistrySecretionMilk allergyFood allergyMicrobiologyBiochemistryGlycosaminoglycan16S ribosomal RNAFirmicutesGeneSeaweed-derived Bioactive CompoundsFood Allergy and Anaphylaxis ResearchFatty Acid Research and Health