Hsp90 inhibitor HSP990 in very low dose upregulates EAAT2 and exerts potent antiepileptic activity
Longze Sha, Ting Chen, Yu Deng, Tingfu Du, Kaili Ma, Wanwan Zhu, Yan Shen, Qi Xu
Abstract
These results support further preclinical studies of HSP990 treatment for temporal lobe epilepsy.
Topics & Concepts
EpilepsyPharmacologyToxicityEpileptogenesisAnticonvulsantHsp90 inhibitorTemporal lobeMedicineHsp90LevetiracetamGenetically modified mouseTransgeneChemistryInternal medicineBiochemistryPsychiatryHeat shock proteinGeneHeat shock proteins researchProtein Structure and DynamicsMitochondrial Function and Pathology