High-Dose Chloroquine for Uncomplicated Plasmodium falciparum Malaria Is Well Tolerated and Causes Similar QT Interval Prolongation as Standard-Dose Chloroquine in Children
Johan Ursing, Lars Rombo, Staffan Eksborg, Lena Larson, Anita Bruvoll, Joel Tärning, Amabélia Rodrigues, Poul‐Erik Kofoed
Abstract
Higher chloroquine doses can effectively treat up to 93 to 96% of malaria infections caused by Plasmodium falciparum carrying the resistance-conferring chloroquine resistance transporter ( pfcrt ) 76T allele. The tolerability of 50 (double the standard dose) and 70 mg/kg total chloroquine doses were assessed in this study. Fifteen 4- to 8-year-old children with uncomplicated malaria were given 10 mg/kg of chloroquine twice daily for 2 days and 5 mg/kg twice daily on the third day.
Topics & Concepts
ChloroquinePlasmodium falciparumMalariaProlongationQT intervalMedicinePharmacologyPiperaquineAnesthesiaInternal medicineArtemisininImmunologyMalaria Research and ControlMosquito-borne diseases and controlDrug-Induced Hepatotoxicity and Protection