Repurposing ibuprofen-loaded microemulsion for the management of Alzheimer’s disease: evidence of potential intranasal brain targeting
Ming Ming Wen, Noha Ismail Khamis Ismail, Maha M. A. Nasra, Amal H. El‐Kamel
Abstract
studies in rats further demonstrated a 4-fold higher brain uptake of ibuprofen from the microemulsion compared to the reference solution and nearly 4-fold and 10-fold higher compared to the intravenous and oral administrations. This study provides an exciting repurposing strategy and new administration route for the treatment of Alzheimer's disease.
Topics & Concepts
IbuprofenMicroemulsionPulmonary surfactantNasal administrationPharmacologyIsopropyl myristateChromatographyZeta potentialPermeationDrugIn vivoPharmacokineticsChemistryMedicineMaterials scienceNanoparticleMembraneNanotechnologyBiochemistryBiologyBiotechnologyAdvancements in Transdermal Drug DeliverySurfactants and Colloidal SystemsAdvanced Drug Delivery Systems