Synthesis and biological evaluation of 1-phenyl-tetrahydro-β-carboline-based first dual PRMT5/EGFR inhibitors as potential anticancer agents
Juan Zhang, Xuliang Liu, Na Sa, Jinhe Zhang, Yong-Si Cai, Kaiming Wang, Wei Xu, Cheng‐Shi Jiang, Kongkai Zhu
Topics & Concepts
Protein arginine methyltransferase 5ChemistryIC50Docking (animal)Epidermal growth factor receptorHeLaPharmacologyEGFR inhibitorsBioavailabilityMethyltransferaseIn vitroBiochemistryReceptorBiologyMethylationGeneMedicineNursingCancer-related gene regulation