Targeting the NLRP3 Inflammasome in Diabetic Nephropathy
Ming Yang, Xi Wang, Yachun Han, Chenrui Li, Ling Wei, Jinfei Yang, Wei Chen, Xuejing Zhu, Lin Sun
Abstract
Diabetic nephropathy (DN) is one of the most common complications of diabetes and the main cause of end-stage renal disease (ESRD). The inflammatory response plays a key role in the pathological process of DN. As the most deeply studied inflammasome, NLRP3 should not be overlooked in DN. Its abnormal activation accelerates DN progression. In this review, we summarize our understanding of the structural composition and activation factors of the NLRP3 inflammasome. Moreover, the relationship between NLRP3 inflammasome activation, and the potential of the NLRP3 inflammasome as a therapeutic target for DN will also be discussed.
Topics & Concepts
InflammasomeDiabetic nephropathyNephropathyDiabetes mellitusPathologicalEnd stage renal diseaseMedicineDiseaseChemistryInflammationImmunologyInternal medicineEndocrinologyInflammasome and immune disordersAdenosine and Purinergic SignalingHeme Oxygenase-1 and Carbon Monoxide