Doxycycline Postexposure Prophylaxis Could Induce Cross-Resistance to Other Classes of Antimicrobials in Neisseria gonorrhoeae: An In Silico Analysis
Thibaut Vanbaelen, Sheeba Santhini Manoharan-Basil, Chris Kenyon
Abstract
ABSTRACT: We found that tetracycline resistance-associated mutations and genes in Neisseria gonorrhoeae are linked to mutations causing resistance to other antimicrobials. Therefore, the use of doxycycline postexposure prophylaxis may select for resistance to other antimicrobials.
Topics & Concepts
Neisseria gonorrhoeaeMedicineDoxycyclineAntimicrobialIn silicoMicrobiologyGonorrheaGonococcal infectionAntibioticsPharmacologyVirologySexually transmitted diseaseSyphilisHuman immunodeficiency virus (HIV)BiologyGeneBiochemistryReproductive tract infections researchBacterial Infections and VaccinesSyphilis Diagnosis and Treatment