Chondroitin sulfate deposited on foxtail millet prolamin/caseinate nanoparticles to improve physicochemical properties and enhance cancer therapeutic effects
Xiao Chen, Yan‐Chao Wu, Pi‐Xian Gong, Yuhe Zhang, Hui‐Jing Li
Abstract
NaCl. FP-NaCas-CS NPs exhibited a higher Cur encapsulation efficiency of 93.4% and re-dispersion capability after lyophilization. Moreover, CS coating promoted selective accumulation in CD44-overexpressing HepG2 cells, resulting in higher inhibition of tumor growth compared to free Cur and FP-NaCas NP-encapsulated Cur. As for comparison, encapsulated Cur exhibited reduced cytotoxicity on normal liver cells L-O2. This preclinical study suggests that FP-NaCas-CS NPs could be very beneficial in terms of encapsulating hydrophobic drugs, improving the effectiveness of cancer therapies and reducing side effects on normal tissues.
Topics & Concepts
ChemistryChondroitin sulfateNanoparticleHydrophobic effectChitosanIonic strengthNuclear chemistryChemical engineeringChromatographyMaterials scienceNanotechnologyBiochemistryOrganic chemistryEngineeringGlycosaminoglycanAqueous solutionProteins in Food SystemsProteoglycans and glycosaminoglycans researchSeaweed-derived Bioactive Compounds