Blue Light Promoted Difluoroalkylation of Aryl Ketones: Synthesis of Quaternary Alkyl Difluorides and Tetrasubstituted Monofluoroalkenes
Kangkui Li, Jingchao Chen, Chunhui Yang, Keyang Zhang, Chunxiang Pan, Baomin Fan
Abstract
A facile and cost-effective method for the preparation of fluoroalkylated compounds has been described by the direct photoexcitation of halofluoroalkanes with blue light absorptivity, enabling the difluoroalkylation of aryl ketones. The methodology has provided an efficient, mild, and catalyst-free synthetic method for quaternary difluoroalkylated arenes and tetrasubstituted monofluoroalkenes.
Topics & Concepts
ChemistryArylAlkylPhotoexcitationCatalysisCombinatorial chemistryPhotochemistryOrganic chemistryNuclear physicsExcited statePhysicsFluorine in Organic ChemistryRadical Photochemical ReactionsInorganic Fluorides and Related Compounds