Catalytic Enantioselective Halocyclizations to Access Benzoxazepinones and Benzoxazecinones
Xiaojian Jiang, Xi Xu, Wei Xu, Pei Yu, Ying‐Yeung Yeung
Abstract
We report a catalytic asymmetric halocyclization protocol to furnish benzoxazepinones and benzoxazecinones using (DHQ)2PHAL as the catalyst. Various halogenated benzoxazepinones and benzoxazecinones were achieved in excellent yields and enantioselectivities under mild conditions. A cocrystal structure of the substrate and the catalyst was studied.
Topics & Concepts
Enantioselective synthesisChemistryCatalysisCocrystalSubstrate (aquarium)Combinatorial chemistryOrganic chemistryMoleculeHydrogen bondGeologyOceanographyVanadium and Halogenation ChemistryChemical Synthesis and ReactionsOxidative Organic Chemistry Reactions