Influence of sex and presence of cardiovascular risk factors on relations between cardiorespiratory fitness and cerebrovascular hemodynamics
Wesley K. Lefferts, Cynthia Weiner, Sara E. Mascone, Jacqueline A. Augustine, Kevin S. Heffernan, Elizabeth C. Schroeder
Abstract
We identify beneficial associations between cardiorespiratory fitness and lower carotid stiffness and pulse pressure as potential mechanisms underlying sex-specific associations of fitness and cerebral pulsatility in females without modifiable risk factors. Greater fitness is beneficially associated with conductance, pulsatile damping, and forward wave energy among adults without risk factors; however, associations are attenuated among adults with modifiable risk factors. These data suggest sex and risk factors may alter cerebrovascular sensitivity to cardiorespiratory fitness.
Topics & Concepts
Cardiorespiratory fitnessHemodynamicsMedicineInternal medicineCardiologyArterial stiffnessPulse wave velocityPulsatile flowTranscranial DopplerBlood pressureMiddle cerebral arteryBody mass indexIschemiaCardiovascular Health and Disease PreventionBlood Pressure and Hypertension StudiesHeart Rate Variability and Autonomic Control