Systems approach reveals distinct and shared signaling networks of the four PGE <sub>2</sub> receptors in T cells
Anna Mari Lone, Piero Giansanti, Marthe Jøntvedt Jørgensen, Enio Gjerga, Aurélien Dugourd, Arjen Scholten, Julio Sáez-Rodríguez, Albert J. R. Heck, Kjetil Taskén
Abstract
-regulated phosphoproteomes in T cell subsets, providing a valuable resource for further research on this physiologically and pathophysiologically important signaling system.
Topics & Concepts
Cell biologySignal transductionProstaglandin E2 receptorBiologyCell signalingReceptorCytotoxic T cellChemistryBiochemistryAgonistIn vitroInflammatory mediators and NSAID effectsPI3K/AKT/mTOR signaling in cancerPharmacogenetics and Drug Metabolism