Irisin deficiency exacerbates diet-induced insulin resistance and cardiac dysfunction in type II diabetes in mice
Jianguo Wang, Yu Zhao, Ling X. Zhang, Patrycja M. Dubielecka, Gangjian Qin, Yvette Chin, Adam C. Gower, Shougang Zhuang, Paul Y. Liu, Ting C. Zhao
Abstract
By utilizing the CRISPR/Cas-9 genome-editing system and high-fat diet (HFD)-induced type II diabetes model, our results provide direct evidence showing that the loss of irisin exacerbates cardiac dysfunction and insulin resistance while promoting myocardial remodeling and a hypertrophic response in HFD-induced diabetes. This study provides new insight into understanding the molecular evidence and the critical role of irisin in modulating insulin resistance and cardiac function in type II diabetes.
Topics & Concepts
Insulin resistanceEndocrinologyInternal medicineType 2 diabetesInsulin receptorInsulinBiologyDiabetes mellitusMedicineAdipose Tissue and MetabolismMitochondrial Function and PathologyMetabolomics and Mass Spectrometry Studies