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Reliable identification of cardiac liability in drug discovery using automated patch clamp: Benchmarking best practices and calibration standards for improved proarrhythmic assessment

Nina Brinkwirth, Kiyoshi Takasuna, Masafumi Doi, Nadine Becker, Alison Obergrussberger, Søren Friis, Hatsue Furukawa, Yuka Hasegawa, Takayuki Oka, Atsushi Ohtsuki, Niels Fertig, Sonja Stoelzle‐Feix

2020Journal of Pharmacological and Toxicological Methods18 citationsDOI

Topics & Concepts

hERGPharmacologyAstemizoleTerfenadineVoltage clampIC50Safety pharmacologyPatch clampChemistryDofetilideMedicineElectrophysiologyDrugIn vitroBiochemistryPotassium channelInternal medicineAtrial fibrillationCardiac electrophysiology and arrhythmiasIon channel regulation and functionPesticide Residue Analysis and Safety
Reliable identification of cardiac liability in drug discovery using automated patch clamp: Benchmarking best practices and calibration standards for improved proarrhythmic assessment | Litcius