A dual-targeting photosensitizer for simultaneous mitochondrial and lysosomal disruption in cancer and antibacterial photodynamic therapy
Chaewoon Cho, K. M. K. Swamy, Bingqing Sun, Gyoungmi Kim, Lei Liu, Won Jun Jang, Juyoung Yoon
Abstract
MCQ-1 is a dual-functional type I photosensitizer, capable of targeting both mitochondria and lysosomes in cancer cells, while also exhibiting selective antibacterial activity against Gram-positive bacteria, including MRSA.
Topics & Concepts
Photodynamic therapyPhotosensitizerReactive oxygen speciesMitochondrionApoptosisOrganelleProgrammed cell deathAutophagyCell biologyDual roleCancer therapyCancer cellCancer researchChemistryCancerBiologyBiochemistryPhotochemistryCombinatorial chemistryOrganic chemistryGeneticsPhotodynamic Therapy Research StudiesNanoplatforms for cancer theranostics