Organoselenium compounds as an enriched source for the discovery of new antimicrobial agents
Louise I. M. Friberg, Angela M. Kavanagh, Maite Amado, Gabrielle J. Lowe, Johannes Zuegg, Michelle Novais de Paula, Abdulmujeeb T. Onawole, Holly Floyd, Ангелина Н. Кравченко, Davy Guan, Alysha G. Elliott, Julia Kuchar, Fabian Mohr, Olga A. Luzina, Нариман Ф. Салахутдинов, Константин П. Волчо, Hafiz Syed Usama Bin Farrukh, Umme Kalsoom, Rahman Shah Zaib Saleem, Joanne T. Blanchfield, Mark A. T. Blaskovich, Karl A. Hansford
Abstract
), and generally retained good activity. Lastly, we compared a handful of matched sulfur and selenium compounds which further highlighted the beneficial impact of this bioisosteric conversion on antifungal activity.
Topics & Concepts
AntifungalAntimicrobialChemistryCombinatorial chemistryMicrobiologyComputational biologyBiologyOrganoselenium and organotellurium chemistrySelenium in Biological SystemsThallium and Germanium Studies