Biological properties of a new class of [Mo2O2S2]-based thiosemicarbazone coordination complexes
Arcadie Fuior, Diana Cebotari, Olga Garbuz, Sergiu Calancea, Aurélian Gulea, Sébastien Floquet
Abstract
This paper deals with the biological properties of 14 coordination complexes assembled from a large panel of thiosemicarbazone ligands and [Mo2O2S2]2+ cluster. The investigation of biological properties evidences a high cancer inhibition activity, and antimicrobial, antifungal and antioxidant properties. The complexes based on phenolic ligands are the most active towards tumor cells, while the pyridine derivatives are the most efficient against bacteria and fungi.
Topics & Concepts
SemicarbazoneChemistryAntimicrobialAntifungalPyridineBiological activityAntioxidantCoordination complexCombinatorial chemistryStereochemistryBacteriaBiochemistryOrganic chemistryMetalMicrobiologyIn vitroBiologyGeneticsMetal complexes synthesis and propertiesMetalloenzymes and iron-sulfur proteinsOrganometallic Compounds Synthesis and Characterization