A biocompatible stapling reaction for <i>in situ</i> generation of constrained peptides
Richard Morewood, Christoph Nitsche
Abstract
stapled peptides. A stapled screening hit showed over 28-fold stronger inhibition than its linear analogue, demonstrating the successful identification of constrained peptide inhibitors.
Topics & Concepts
Biocompatible materialPeptideCombinatorial chemistryChemistryAmino acidCysteinePeptide synthesisIn situProteaseMetabolic stabilityReagentOligopeptideBiochemistryEnzymeIn vitroOrganic chemistryBiomedical engineeringMedicineChemical Synthesis and AnalysisClick Chemistry and ApplicationsRNA and protein synthesis mechanisms