Litcius/Paper detail

Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors

Ben Chetter, E. Kyriakis, Daniel Barr, Aikaterini G. Karra, Elisabeth Katsidou, Symeon M. Koulas, Vassiliki T. Skamnaki, Timothy J. Snape, Anna‐Maria G. Psarra, D.D. Leonidas, Joseph M. Hayes

2020Bioorganic Chemistry22 citationsDOI

Topics & Concepts

ChemistryFlavonoidIn vitroGlycogen phosphorylaseKineticsBiochemistryEx vivoGlycogen synthaseIn vivoQM/MMEnzymeStereochemistryCatalysisAntioxidantQuantum mechanicsBiotechnologyPhysicsBiologyCarbohydrate Chemistry and SynthesisChemical Synthesis and AnalysisGlycosylation and Glycoproteins Research
Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors | Litcius