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Thrombospondin-1–CD47 signaling contributes to the development of T cell exhaustion in cancer

Chien‐Huan Weng, Anais Assouvie, Lauren Dong, Jean‐Christophe Beltra, Sadna Budhu, Levi Mangarin, Yacine Marouf, Lucia Morgado-Palacin, Cailian Liu, Sébastien Monette, Jonathan F. Khan, Isabell Schulze, Dmitriy Zamarin, Linda Hamadene, Fadi Samaan, Daniel Hirschhorn, Stephane Pourpe, David Schröder, Roberta Zappasodi, Pamela M. Holland, Niroshana Anandasabapathy, E. John Wherry, Jedd D. Wolchok, Taha Merghoub

2025Nature Immunology7 citationsDOI

Topics & Concepts

Downregulation and upregulationT cellCancer researchImmune systemImmunotherapyCancerCancer immunotherapyEffectorBlockadeCell biologyBiologyCellImmunologyCD47Immune checkpointImmunitySignal transductionFunction (biology)Cancer cellCytotoxic T cellSensitizationExtracellularAntigenCTLA-4T-cell receptorPD-L1Antigen presentationExtracellular matrixChemistryPhagocytosis and Immune RegulationInvertebrate Immune Response MechanismsAngiogenesis and VEGF in Cancer
Thrombospondin-1–CD47 signaling contributes to the development of T cell exhaustion in cancer | Litcius