Dysregulation and implications of N6-methyladenosine modification in renal cell carcinoma
Yaohai Wu, Shiqiang Zhang, Chujie Chen, Jun Pang
Abstract
Abstract Increasing evidence indicates that N 6 -methyladenosine (m 6 A) methylation modification serves important functions in biological metabolism. Dysregulation of m 6 A regulators is related to the progression of different malignancies, including renal cell carcinoma (RCC). Recent studies have reported preliminary findings on the influence of m 6 A regulator dysregulation on RCC tumorigenesis and development. However, no comprehensive review that integrates and analyzes the roles of m 6 A modification in RCC has been published to date. In this review, we focus on the dysregulation of m 6 A regulators as it relates to RCC tumorigenesis and development, as well as possible applications of m 6 A modification in RCC diagnosis and therapeutics.