Heterozygous SOD2 deletion deteriorated chronic intermittent hypoxia-induced lung inflammation and vascular remodeling through mtROS-NLRP3 signaling pathway
Jieqiong Song, Liyan Jiang, Cuiping Fu, Xu Wu, Zilong Liu, Liang Xie, Xiaodan Wu, Shengyu Hao, Shanqun Li
Topics & Concepts
SOD2Oxidative stressInflammasomeMitochondrial ROSInflammationGene knockdownReactive oxygen speciesSuperoxide dismutaseSOD1Proinflammatory cytokineChemistryHypoxia (environmental)ImmunologyEndocrinologyCell biologyBiologyApoptosisBiochemistryOxygenOrganic chemistryObstructive Sleep Apnea ResearchNeuroscience of respiration and sleepChronic Obstructive Pulmonary Disease (COPD) Research