Percutaneous electrical stimulation-induced muscle contraction prevents the decrease in ribosome RNA and ribosome protein during pelvic hindlimb suspension
Takaya Kotani, Yuki Tamura, Karina Kouzaki, Hikaru Kato, Mako Isemura, Koichi Nakazato
Abstract
Muscle inactivity reduces ribosome synthesis and content during atrophy. Whether percutaneous electrical muscle stimulation (pEMS)-induced muscle contraction rescues the ribosome synthesis and content during muscle unloading is unclear. Using a mouse hindlimb-unloading model with pelvic suspension, we provide evidence that daily pEMS-induced muscle contraction during hindlimb unloading rescues the reduction in the expression of some ribosome synthesis-related proteins and ribosome content in the gastrocnemius muscle.
Topics & Concepts
HindlimbContraction (grammar)Muscle atrophyStimulationMuscle contractionAtrophyRibosomeProtein biosynthesisGastrocnemius muscleSkeletal muscleAnatomyBiologyEndocrinologyChemistryInternal medicineMedicineRNABiochemistryGeneMuscle Physiology and DisordersCardiomyopathy and Myosin StudiesGenetic Neurodegenerative Diseases