A gut–brain axis on-a-chip platform for drug testing challenged with donepezil
Francesca Fanizza, Simone Perottoni, Lucia Boeri, Francesca Donnaloja, F Negro, francesca pugli, Gianluigi Forloni, Carmen Giordano, Diego Albani
Abstract
Current drug development pipelines are time-consuming and prone to a significant percentage of failure, partially due to the limited availability of advanced human preclinical models able to better replicate the in vivo complexity of our body.
Topics & Concepts
DonepezilDrugChipPharmacologyComputer scienceMedicineEngineeringInternal medicineDementiaElectrical engineeringDiseaseNeuroscience and Neural EngineeringNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function