Exercise maintains bone homeostasis by promoting osteogenesis through STAT3
Xiangru Huang, Yanfei Zhu, Siyuan Sun, Xin Gao, Yiling Yang, Hongyuan Xu, Anting Jin, Yuanqi Liu, Hanbing Jia, Qinggang Dai, Lingyong Jiang
Abstract
and partly rescued exercise loss-induced disuse bone loss by improving osteogenesis in the tail suspension model. Taken together, our study revealed the essential role of STAT3 in maintaining exercise-mediated bone homeostasis. In addition, STAT3 might act as a potential target for osteoporosis caused by exercise loss.
Topics & Concepts
OsteoblastBone remodelingChemistrySTAT3EndocrinologyInternal medicineCell biologyMechanotransductionSTAT proteinOsteoporosisHomeostasisBone marrowMedicineSignal transductionBiologyIn vitroBiochemistryBone Metabolism and DiseasesCytokine Signaling Pathways and InteractionsMuscle Physiology and Disorders