The potential role of hydrogen sulfide in cancer cell apoptosis
Wei Gao, Yafang Liu, Yanxia Zhang, Yan Wang, Yuqing Jin, Hang Yuan, Xiaoyi Liang, Xin‐Ying Ji, Qiying Jiang, Dongdong Wu
Abstract
Abstract For a long time, hydrogen sulfide (H 2 S) has been considered a toxic compound, but recent studies have found that H 2 S is the third gaseous signaling molecule which plays a vital role in physiological and pathological conditions. Currently, a large number of studies have shown that H 2 S mediates apoptosis through multiple signaling pathways to participate in cancer occurrence and development, for example, PI3K/Akt/mTOR and MAPK signaling pathways. Therefore, the regulation of the production and metabolism of H 2 S to mediate the apoptotic process of cancer cells may improve the effectiveness of cancer treatment. In this review, the role and mechanism of H 2 S in cancer cell apoptosis in mammals are summarized.