Water soluble transition metal [Ni(<scp>ii</scp>), Cu(<scp>ii</scp>) and Zn(<scp>ii</scp>)] complexes of <i>N</i>-phthaloylglycinate bis(1,2-diaminocyclohexane). DNA binding, pBR322 cleavage and cytotoxicity
Salman Khursheed, Hifzur R. Siddique, Sartaj Tabassum, Farukh Arjmand
Abstract
and the bioactive 1,2-diaminocyclohexane fragment in these complexes plays an instrumental role in anticancer activity.
Topics & Concepts
ChemistryCrystallographyOctahedral molecular geometryStereochemistryLigand (biochemistry)Electron paramagnetic resonanceOctahedronMetalMoleculeCrystal structureOrganic chemistryBiochemistryReceptorPhysicsNuclear magnetic resonanceMetal complexes synthesis and propertiesOrganometallic Compounds Synthesis and CharacterizationCrystal structures of chemical compounds