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New fused pyrimidine derivatives with anticancer activity: Synthesis, topoisomerase II inhibition, apoptotic inducing activity and molecular modeling study

Mohamed T. M. Nemr, Asmaa M. AboulMagd

2020Bioorganic Chemistry79 citationsDOI

Topics & Concepts

TopoisomeraseChemistryIC50PyrimidineApoptosisCell cycleCell cultureEnzymeStereochemistryCell cycle checkpointDoxorubicinCancer cellGrowth inhibitionBiochemistryCancerIn vitroBiologyChemotherapyGeneticsCancer therapeutics and mechanismsSynthesis and biological activityQuinazolinone synthesis and applications
New fused pyrimidine derivatives with anticancer activity: Synthesis, topoisomerase II inhibition, apoptotic inducing activity and molecular modeling study | Litcius