Design, synthesis, and biological evaluation of 2,4-diaminopyrimidine derivatives as potent Hematopoietic Progenitor Kinase 1 (HPK1) inhibitors
Siyu Fu, Jiakuan Wei, Chunting Li, Na Zhang, Hao Yue, Ao Yang, Jichang Xu, Kuan Dong, Yongpeng Xing, Minghui Tong, Xuan Shi, Zhiguo Xi, Han Wang, Yunlei Hou, Yanfang Zhao
Topics & Concepts
ChemistryHaematopoiesisKinaseProgenitor cellPharmacologyCell biologyCombinatorial chemistryBiochemistryStem cellBiologyMelanoma and MAPK PathwaysPI3K/AKT/mTOR signaling in cancerProtein Degradation and Inhibitors