Synthesis, molecular modelling and biological activity of some pyridazinone derivatives as selective human monoamine oxidase-B inhibitors
Zeynep Özdemir, Mehmet Abdullah Alagöz, Harun Uslu, Arzu Karakurt, Açelya Erikçi, Gülberk Uçar, Mehtap Uysal
Topics & Concepts
ADMEMonoamine oxidaseIn silicoChemistryMonoamine oxidase BPharmacologyIn vivoDocking (animal)PiperazineMonoamine neurotransmitterIn vitroBiochemistryEnzymeBiologySerotoninReceptorMedicineOrganic chemistryGeneBiotechnologyNursingCholinesterase and Neurodegenerative DiseasesParkinson's Disease Mechanisms and TreatmentsEnzyme function and inhibition