The epidemiology and virulence of carbapenem-resistant Pseudomonas aeruginosa in China
Ying Zhu, Peiyao Jia, Wei Yu, Xiaobing Chu, Xiaoyu Liu, Qiwen Yang
Abstract
We read with interest the Article by the Antibacterial Resistance Leadership Group and Multi-Drug Resistant Organism Network Investigators, which described the divergent global distribution of carbapenem-resistant Pseudomonas aeruginosa, and the increasingly serious therapeutic problems it causes.1 There are three main mechanisms of resistance to P aeruginosa: producing or over-expressing β-lactamase, outer membrane protein mutation, and overexpression of the efflux pump system.2,3 The virulence of P aeruginosa is closely connected to four key effectors (ExoU, ExoT, ExoY, and ExoS) in the type III secretion system which help inject the toxic proteins into host cells.
Topics & Concepts
Pseudomonas aeruginosaMicrobiologyEffluxVirulenceBiologyCarbapenemType three secretion systemImipenemBacteriaGeneAntibioticsGeneticsAntibiotic Resistance in BacteriaBacterial biofilms and quorum sensingVibrio bacteria research studies