Nanoparticle-Based Co-Delivery of siRNA and Paclitaxel for Dual-Targeting of Glioblastoma
Jun Yang, Zhang Qiang, Yanxiu Liu, Xinjie Zhang, Wenjun Shan, Shefang Ye, Xi Zhou, Yunlong Ge, Xiumin Wang, Lei Ren
Abstract
Aim: To explore the therapeutic effect of nanoparticle-based dual-targeting delivery of antitumor agents for glioblastoma treatment. Materials & methods: A hepatitis B core protein-virus-like particle (VLP)-based dual-targeting delivery system was designed with the primary brain targeting peptide TGN for blood–brain barrier penetration and tumor vascular preferred ligand RGD (arginine–glycine–aspartic acid) for glioblastoma targeting. Chemo- and gene-therapeutic agents of paclitaxel and siRNA were co-packaged inside the vehicle. Results: The results demonstrated efficient delivery of the packaged agents to invasive tumor sites. The combination of chemo- and gene-therapies demonstrated synergistic antitumor effects through enhancing necrosis and apoptosis, as well as being able to inhibit tumor invasion with minimal cytotoxicity. Conclusion: Our hepatitis B core-VLP-based dual-targeting delivery of chemo- and gene-therapeutic agents possesses a synergistic antitumor effect for glioblastoma therapy.