Stroke by inducing HDAC9-dependent deacetylation of HIF-1 and Sp1, promotes TfR1 transcription and GPX4 reduction, thus determining ferroptotic neuronal death
Luca Sanguigno, Natascia Guida, Serenella Anzilotti, Ornella Cuomo, Luigi Mascolo, Angelo Serani, Paola Brancaccio, Giuseppina Pennacchio, Ester Licastro, Giuseppe Pignataro, Pasquale Molinaro, Lucio Annunziato, Luigi Formisano
Abstract
models of stroke.
Topics & Concepts
Gene silencingTranscription factorBiologyChemistryCell biologyMolecular biologyBiochemistryGeneHistone Deacetylase Inhibitors ResearchEpigenetics and DNA MethylationMicroRNA in disease regulation