Microwave-assisted organic acid–base-co-catalyzed tandem Meinwald rearrangement and annulation of styrylepoxides
Yi Shi, Siqi Li, Yang Lu, Zizhen Zhao, Pingfan Li, Jiaxi Xu
Abstract
A novel organic acid-base-co-catalyzed conversion of styrylepoxides into [1,1'-biaryl]-3-carbaldehydes was realized under microwave irradiation. Styrylepoxides first underwent an acid-catalyzed Meinwald rearrangement followed by a tandem base-catalyzed Michael addition, aldol addition, and aromatization sequence to generate [1,1'-biaryl]-3-carbaldehydes.
Topics & Concepts
TandemAromatizationAnnulationCatalysisChemistryMicrowave irradiationBase (topology)Combinatorial chemistryOrganic chemistryMaterials scienceComposite materialMathematical analysisMathematicsAsymmetric Synthesis and CatalysisSynthetic Organic Chemistry MethodsCatalytic Cross-Coupling Reactions