Tropylium‐BF <sub>4</sub> as Organocatalyst for Efficient Synthesis of Nitriles from Aldoximes; Synthetic Scope and Mechanistic Insights
Athmanand Anchi, Suraj M. Sutar, Rajesh G. Kalkhambkar, Gabriela L. Borosky, Kenneth K. Laali
Abstract
Abstract Structurally diverse aldoximes were conveniently transformed within minutes to the corresponding nitriles by using tropylium BF 4 as organocatalyst, in 1‐butyl‐3‐methylimidazolium ionic liquids (BMIM‐ILs) as solvent, under microwave irradiation. The scope of this convenient, cyanide free, process for nitrile synthesis was explored, and DFT computations were employed to shed light on the mechanistic steps of this catalytic reaction leading to dehydration.
Topics & Concepts
ChemistryIonic liquidNitrileScope (computer science)CatalysisCyanideMicrowave irradiationCombinatorial chemistrySolventOrganic chemistryProgramming languageComputer scienceChemical Synthesis and ReactionsInorganic and Organometallic ChemistryIonic liquids properties and applications