PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression
Xin Yang, Zhe Wang, Svetlana N. Samovich, Alexander A. Kapralov, Andrew A. Amoscato, Vladimir A. Tyurin, Haider H. Dar, Zhiming Li, Shoufu Duan, Ning Kon, Delin Chen, Benjamin Tycko, Zhiguo Zhang, Xuejun Jiang, Hülya Bayır, Brent R. Stockwell, Valerian E. Kagan, Wei Gu
Topics & Concepts
Phosphatidic acidReactive oxygen speciesCell biologyCancer researchLipid peroxidationIn vivoBiologyGPX4ChemistryBiochemistryOxidative stressGeneticsSuperoxide dismutasePhospholipidGlutathione peroxidaseMembraneFerroptosis and cancer prognosisEpigenetics and DNA MethylationCancer-related molecular mechanisms research