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PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression

Xin Yang, Zhe Wang, Svetlana N. Samovich, Alexander A. Kapralov, Andrew A. Amoscato, Vladimir A. Tyurin, Haider H. Dar, Zhiming Li, Shoufu Duan, Ning Kon, Delin Chen, Benjamin Tycko, Zhiguo Zhang, Xuejun Jiang, Hülya Bayır, Brent R. Stockwell, Valerian E. Kagan, Wei Gu

2024Cell Metabolism55 citationsDOIOpen Access PDF

Topics & Concepts

Phosphatidic acidReactive oxygen speciesCell biologyCancer researchLipid peroxidationIn vivoBiologyGPX4ChemistryBiochemistryOxidative stressGeneticsSuperoxide dismutasePhospholipidGlutathione peroxidaseMembraneFerroptosis and cancer prognosisEpigenetics and DNA MethylationCancer-related molecular mechanisms research
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression | Litcius