Histone demethylase JMJD3 protects against renal fibrosis by suppressing TGFβ and Notch signaling and preserving PTEN expression
Chao Yu, Chongxiang Xiong, Jinhua Tang, Xiying Hou, Na Liu, George Bayliss, Shougang Zhuang
Abstract
These results indicate that JMJD3 confers anti-fibrotic effects by limiting activation of multiple profibrotic signaling pathways and suggest that JMJD3 modulation may have therapeutic effects for chronic kidney disease.
Topics & Concepts
PTENDemethylaseNotch signaling pathwayHistoneCancer researchTransforming growth factorFibrosisMedicineSignal transductionBiologyChemistryInternal medicineCell biologyPI3K/AKT/mTOR pathwayBiochemistryGeneRenal cell carcinoma treatmentRenal and related cancersEpigenetics and DNA Methylation