Skeletal muscle antagonizes antiviral CD8 <sup>+</sup> T cell exhaustion
Jingxia Wu, Nina Weisshaar, Agnes Hotz‐Wagenblatt, Alaa Madi, Sicong Ma, Alessa Mieg, Marvin Hering, Kerstin Möhr, Tilo Schlimbach, Helena Borgers, Guoliang Cui
Abstract
T cell responses. We conclude that skeletal muscle antagonizes T cell exhaustion by protecting T cell proliferative potential from inflammation and replenishing the effector T cell progeny pool in lymphoid organs.
Topics & Concepts
Skeletal muscleCytotoxic T cellVirologyCD8ImmunologyBiologyCell biologyEndocrinologyImmune systemGeneticsIn vitroExercise and Physiological ResponsesImmune Cell Function and InteractionAdipose Tissue and Metabolism