Type I Interferon Promotes Humoral Immunity in Viral Vector Vaccination
Chaojie Zhong, Feng‐Liang Liu, Renee J. Hajnik, Yao Lei, Kangjing Chen, Meirong Wang, Yuejin Liang, Jiaren Sun, Lynn Soong, Wei Hou, Haitao Hu
Abstract
mice as a model, we report that type I IFN signaling promotes humoral immunity in MVA vaccination, including vaccine-induced antibody, B-cell, and Tfh responses. Our findings provide insights that not only add to our basic understanding of host-viral vector interactions but also will aid in improving vaccine design by potentially modulating type I IFN and its associated innate immune pathways in viral vector vaccination.
Topics & Concepts
Innate immune systemBiologyVirologyVaccinationImmune systemViral vectorInterferonVacciniaImmunityModified vaccinia AnkaraAcquired immune systemHumoral immunityImmunologyIntrinsic immunityInflammasomeRecombinant DNAInflammationBiochemistryGeneinterferon and immune responsesvaccines and immunoinformatics approachesHerpesvirus Infections and Treatments