RNA dependent RNA polymerase (RdRp) as a drug target for SARS-CoV2
Avinash Mishra, Anurag S. Rathore
Abstract
binding at a catalytic site. In contrast, Galidesivir may not have direct anti-RdRp activity but it can induce a conformational change in the RNA polymerase.
Topics & Concepts
RNA polymeraseRNA-dependent RNA polymeraseBinding siteChemistryStereochemistryRNAActive siteEnzymePolymeraseBiochemistryBiologyGeneSARS-CoV-2 and COVID-19 ResearchViral gastroenteritis research and epidemiologyViral Infections and Immunology Research