Atroposelective synthesis of axially chiral indolizinylpyrroles by catalytic asymmetric Paal–Knorr reaction
Wen Zhan, Jiameng Hu, Xiaoyun Chen, Gen Luo, Xiaoxiao Song
Abstract
-indolizinylpyrrole through the chiral phosphoric acid (CPA) catalyzed Paal-Knorr reaction of 3-aminoindolizines and 1,4-diketones. The reaction features mild reaction conditions, broad substrate scope and excellent enantioselectivity. Moreover, this method provides a facile approach to a novel axially chiral indolizine-pyrrole framework.
Topics & Concepts
CatalysisAxial symmetryChemistryCombinatorial chemistryOrganic chemistryComputational chemistryPhysicsQuantum mechanicsAxial and Atropisomeric Chirality SynthesisAlgebraic structures and combinatorial modelsMolecular spectroscopy and chirality