Mavacamten: First Approval
Susan J. Keam
Abstract
Mavacamten (Camzyos™) is an oral small-molecule cardiac myosin inhibitor developed by MyoKardia, Inc., a wholly owned subsidiary of Bristol Myers Squibb, for the treatment of hypertrophic cardiomyopathy (HCM) and diseases of diastolic dysfunction. In April 2022, mavacamten was approved for use in the USA in the treatment of adults with symptomatic New York Heart Association (NYHA) class II-III obstructive HCM to improve functional capacity and symptoms. This article summarizes the milestones in the development of mavacamten leading to this first approval for the treatment of adults with symptomatic NYHA class II-III obstructive HCM.
Topics & Concepts
MedicineHypertrophic cardiomyopathyInternal medicineCardiologyCardiomyopathyHeart failureCardiomyopathy and Myosin StudiesCardiovascular Effects of ExerciseCardiovascular Function and Risk Factors